Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy

Salah Dajani; Virginia B. Hill; John A. Kalapurakal; Craig M. Horbinski; Eric G. Nesbit; Sean Sachdev; Amulya Yalamanchili; Tarita O. Thomas

doi:10.3390/jcm11195961

Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy

Salah Dajani, Virginia B. Hill, John A. Kalapurakal, Craig M. Horbinski, Eric G. Nesbit, Sean Sachdev, Amulya Yalamanchili, Tarita O. Thomas^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as well as the diagnostic imaging characteristics of this tumor. In addition, factors that affect prognosis such as differentiating progression from treatment effect is discussed. The role of MRI guided radiation therapy and how this technology may provide a mechanism to improve the care of patients with this disease are described.

Original language	English (US)
Article number	5961
Journal	Journal of Clinical Medicine
Volume	11
Issue number	19
DOIs	https://doi.org/10.3390/jcm11195961
State	Published - Oct 2022

Keywords

GBM
MRI guided adaptive radiation therapy
MRI guided radiation therapy
Machine learning
imaging of GBM

ASJC Scopus subject areas

General Medicine

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10.3390/jcm11195961

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title = "Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy",

abstract = "Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as well as the diagnostic imaging characteristics of this tumor. In addition, factors that affect prognosis such as differentiating progression from treatment effect is discussed. The role of MRI guided radiation therapy and how this technology may provide a mechanism to improve the care of patients with this disease are described.",

keywords = "GBM, MRI guided adaptive radiation therapy, MRI guided radiation therapy, Machine learning, imaging of GBM",

author = "Salah Dajani and Hill, {Virginia B.} and Kalapurakal, {John A.} and Horbinski, {Craig M.} and Nesbit, {Eric G.} and Sean Sachdev and Amulya Yalamanchili and Thomas, {Tarita O.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

doi = "10.3390/jcm11195961",

language = "English (US)",

volume = "11",

journal = "Journal of Clinical Medicine",

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T1 - Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy

AU - Dajani, Salah

AU - Hill, Virginia B.

AU - Kalapurakal, John A.

AU - Horbinski, Craig M.

AU - Nesbit, Eric G.

AU - Sachdev, Sean

AU - Yalamanchili, Amulya

AU - Thomas, Tarita O.

PY - 2022/10

Y1 - 2022/10

N2 - Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as well as the diagnostic imaging characteristics of this tumor. In addition, factors that affect prognosis such as differentiating progression from treatment effect is discussed. The role of MRI guided radiation therapy and how this technology may provide a mechanism to improve the care of patients with this disease are described.

AB - Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as well as the diagnostic imaging characteristics of this tumor. In addition, factors that affect prognosis such as differentiating progression from treatment effect is discussed. The role of MRI guided radiation therapy and how this technology may provide a mechanism to improve the care of patients with this disease are described.

KW - GBM

KW - MRI guided adaptive radiation therapy

KW - MRI guided radiation therapy

KW - Machine learning

KW - imaging of GBM

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DO - 10.3390/jcm11195961

M3 - Review article

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JF - Journal of Clinical Medicine

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Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy

Abstract

Keywords

ASJC Scopus subject areas

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