Imaging of posttransplantation lymphoproliferative disorder after solid organ transplantation

Amir A. Borhani, Keyanoosh Hosseinzadeh*, Omar Almusa, Alessandro Furlan, Michael Nalesnik

*Corresponding author for this work

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of diseases that represent uncommon complications of transplantation and can lead to significant morbidity and mortality. PTLD is most prevalent during the first year following transplantation and occurs most frequently in multiorgan transplant recipients, followed by bowel, heart-lung, and lung recipients. It may involve any of the organ systems, with disease manifestation and the anatomic pattern of organ involvement being highly dependent on the type of transplantation. The current classification system includes four subtypes that have different prognoses requiring different treatment strategies. Tissue sampling is necessary for diagnosis and further subcategorization. The majority of cases are characterized by B-cell proliferation and are related to infection from Epstein-Barr virus. Knowledge of the distribution and radiologic features of PTLD allows the radiologist to play a pivotal role in making an early diagnosis and in guiding biopsy.

Original languageEnglish (US)
Pages (from-to)981-1000
Number of pages20
JournalRadiographics
Volume29
Issue number4
DOIs
StatePublished - Jul 2009
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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