Imaging studies and biomarkers to detect clinically meaningful vesicoureteral reflux

Michaella Maloney Prasad*, Earl Y. Cheng

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The work-up of a febrile urinary tract infection is generally performed to detect vesicoureteral reflux (VUR) and its possible complications. The imaging modalities most commonly used for this purpose are renal-bladder ultrasound, voiding cystourethrogram and dimercapto-succinic acid scan. These studies each contribute valuable information, but carry individual benefits and limitations that may impact their efficacy. Biochemical markers are not commonly used in pediatric urology to diagnose or differentiate high-risk disease, but this is the emerging frontier, which will hopefully change our approach to VUR in the future. As it becomes more apparent that there is tremendous clinical variation within grades of VUR, the need to distinguish clinically significant from insignificant disease grows. The unfortunate truth about VUR is that recommendations for treatment may be inconsistent. Nuances in clinical decision-making will always exist, but opinions for medical versus surgical intervention should be more standardized, based on risk of injury to the kidney.

Original languageEnglish (US)
Pages (from-to)S23-S31
JournalInvestigative and Clinical Urology
StatePublished - 2017


  • Biomarkers
  • Technetium Tc 99m dimercaptosuccinic acid
  • Urinary tract infections
  • Urography
  • Vesicoureteral reflux

ASJC Scopus subject areas

  • Urology

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