Imipramine binding in subpopulations of normal human blood platelets

R. C. Arora, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Imipramine binding was studied in platelet membranes isolated with different proportions of heavy (young) and light (old) platelets. The Bmax, a measure of the number of binding sites, was greater in the heavier platelets than in the light platelets. However, the dissociation constant Kd (a reflection of the affinity of imipramine binding) was greater in the lighter platelets compared to the heavy platelets. These results indicate that difference in Kd and Bmax in particular membrane preparation, could be due to the differences in the relative proportion of heavy and light platelets.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalBiological psychiatry
Volume19
Issue number2
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Biological Psychiatry

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