Immobilization using dental material casts facilitates accurate serial and multimodality small animal imaging

Chad R. Haney, Xiaobing Fan, Adrian D. Parasca, Gregory S. Karczmar, Howard J. Halpern, Charles A. Pelizzari

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    Custom disposable patient immobilization systems that conform to the patient's body contours are commonly used to facilitate accurate repeated patient setup for imaging and treatment in radiation therapy. However, in small-animal imaging, immobilization is often overlooked or done in a way that is not conducive to reproducible positioning. This has a negative impact on the potential for accurate analysis of serial or multimodality imaging. We present the use of vinyl polysiloxane dental impression material for immobilization of mice for imaging. Four different materials were examined to identify any potential artifacts using magnetic resonance techniques. A water phantom placed inside the cast was used at 4.7 T with magnetic resonance imaging and showed no effect at the center of the image when compared with images without the cast. A negligible effect was seen near the ends of the coil. Each material had no detectable signal using electron paramagnetic resonance imaging at 9 mT. The use of dental material also greatly enhances the use of fiducial markers that can be embedded in the mold. Therefore, image registration is simplified as the immobilization of the animal and fiducials together helps in translating from one image coordinate system to another.

    Original languageEnglish (US)
    Pages (from-to)138-144
    Number of pages7
    JournalConcepts in Magnetic Resonance Part B: Magnetic Resonance Engineering
    Volume33
    Issue number2
    DOIs
    StatePublished - Apr 2008

    Keywords

    • Dental impression materials
    • Image registration
    • Imaging
    • Patient immobilization

    ASJC Scopus subject areas

    • Radiological and Ultrasound Technology
    • Radiology Nuclear Medicine and imaging
    • Spectroscopy
    • Physical and Theoretical Chemistry

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