Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond

Surya Pandey, Meghan E. Cholak, Rishita Yadali, Jeffrey A. Sosman, Marie-Pier Tetreault, Deyu Fang, Seth Michaels Pollack, Sacha Gnjatic, Rebecca Obeng, H. Kim Lyerly, Adam M. Sonabend, José A. Guevara-Patiño, Lisa H. Butterfield, Bin Zhang, Holden T. Maecker*, I. Caroline Le Poole*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


As part of a symposium, current and former directors of Immune Monitoring cores and investigative oncologists presented insights into the past, present and future of immune assessment. Dr. Gnjatic presented a classification of immune monitoring technologies ranging from universally applicable to experimental protocols, while emphasizing the need for assay harmonization. Dr. Obeng discussed physiologic differences among CD8 T cells that align with anti-tumor responses. Dr. Lyerly presented the Soldano Ferrone lecture, commemorating the passionate tumor immunologist who inspired many, and covered a timeline of monitoring technology development and its importance to immuno-oncology. Dr. Sonabend presented recent achievements in glioblastoma treatment, accentuating the range of monitoring techniques that allowed him to refine patient selection for clinical trials. Dr. Guevara-Patiño focused on hypoxia within the tumor environment and stressed that T cell viability is not to be confused with functionality. Dr. Butterfield accentuated monitoring of dendritic cell metabolic (dys)function as a determinant for tumor vaccine success. Lectures were interspersed with select abstract presentations. To summarize the concepts, Dr. Maecker from Stanford led an informative forum discussion, pointing towards the future of immune monitoring. Immune monitoring continues to be a guiding light towards effective immunotherapeutic strategies.

Original languageEnglish (US)
Article number475
Issue number3
StatePublished - Feb 2024


  • biomarkers
  • cancer therapy
  • core facility
  • immune cells
  • immune monitoring
  • vaccine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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