Immune Checkpoint Inhibitors in Glioblastoma IDHwt Treatment: A Systematic Review

Archit Bharathwaj Baskaran; Olivia A. Kozel; Omkar Venkatesh; Derek A. Wainwright; Adam M. Sonabend; Amy B. Heimberger; Rimas Vincas Lukas

doi:10.3390/cancers16244148

Immune Checkpoint Inhibitors in Glioblastoma IDHwt Treatment: A Systematic Review

Archit Bharathwaj Baskaran^*, Olivia A. Kozel, Omkar Venkatesh, Derek A. Wainwright, Adam M. Sonabend, Amy B. Heimberger, Rimas Vincas Lukas

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

We present a systematic review of the clinical trials of immune checkpoint inhibitors in GBM. This collates a substantial amount of data in a fashion that is manageable for the reader. It is anticipated that this will have value for the clinician managing this patient population, the clinical trialist contemplating the next therapeutic trials, and the scientist considering future investigations in immunotherapy.

Original language	English (US)
Article number	4148
Journal	Cancers
Volume	16
Issue number	24
DOIs	https://doi.org/10.3390/cancers16244148
State	Published - Dec 2024

Funding

Some of the authors for this work received funding by the NIH grants CA120813 (ABH), NS120547 (ABH), P50CA221747 (ABH; AMS; RVL), NS110703 (AMS), 1U19CA264338 (AMS), CA245969 (AMS) and generous philanthropic support from Vic and Tina Kedaitis.

Keywords

CTLA4
LAG3
PD-L1
PD-L2
PD1
glioblastoma
immune checkpoint inhibition

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers16244148

Cite this

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title = "Immune Checkpoint Inhibitors in Glioblastoma IDHwt Treatment: A Systematic Review",

abstract = "We present a systematic review of the clinical trials of immune checkpoint inhibitors in GBM. This collates a substantial amount of data in a fashion that is manageable for the reader. It is anticipated that this will have value for the clinician managing this patient population, the clinical trialist contemplating the next therapeutic trials, and the scientist considering future investigations in immunotherapy.",

keywords = "CTLA4, LAG3, PD-L1, PD-L2, PD1, glioblastoma, immune checkpoint inhibition",

author = "Baskaran, {Archit Bharathwaj} and Kozel, {Olivia A.} and Omkar Venkatesh and Wainwright, {Derek A.} and Sonabend, {Adam M.} and Heimberger, {Amy B.} and Lukas, {Rimas Vincas}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

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doi = "10.3390/cancers16244148",

language = "English (US)",

volume = "16",

journal = "Cancers",

issn = "2072-6694",

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T2 - A Systematic Review

AU - Baskaran, Archit Bharathwaj

AU - Kozel, Olivia A.

AU - Venkatesh, Omkar

AU - Wainwright, Derek A.

AU - Sonabend, Adam M.

AU - Heimberger, Amy B.

AU - Lukas, Rimas Vincas

PY - 2024/12

Y1 - 2024/12

N2 - We present a systematic review of the clinical trials of immune checkpoint inhibitors in GBM. This collates a substantial amount of data in a fashion that is manageable for the reader. It is anticipated that this will have value for the clinician managing this patient population, the clinical trialist contemplating the next therapeutic trials, and the scientist considering future investigations in immunotherapy.

AB - We present a systematic review of the clinical trials of immune checkpoint inhibitors in GBM. This collates a substantial amount of data in a fashion that is manageable for the reader. It is anticipated that this will have value for the clinician managing this patient population, the clinical trialist contemplating the next therapeutic trials, and the scientist considering future investigations in immunotherapy.

KW - CTLA4

KW - LAG3

KW - PD-L1

KW - PD-L2

KW - PD1

KW - glioblastoma

KW - immune checkpoint inhibition

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U2 - 10.3390/cancers16244148

DO - 10.3390/cancers16244148

M3 - Review article

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SN - 2072-6694

VL - 16

JO - Cancers

JF - Cancers

IS - 24

M1 - 4148

ER -

Immune Checkpoint Inhibitors in Glioblastoma IDHwt Treatment: A Systematic Review

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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