Immune Checkpoint Inhibitors in Gliomas

Aaron C. Tan, Amy B. Heimberger, Mustafa Khasraw*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Purpose of Review: Malignant gliomas result in disproportionately high morbidity and mortality compared with other primary tumors, and progression of disease is inevitable. Novel therapies to improve outcomes are needed and immune checkpoint inhibitors hold significant promise. Recent Findings: A limited body of preclinical evidence suggests that checkpoint inhibitors may be effective treatment for gliomas. Biomarkers to identify characteristics of gliomas responsive to these therapies will be essential. These may include mismatch repair deficiency and high mutational load that might be germline, somatic, or acquired after therapy. Evidence on the use of immune checkpoint inhibitors in gliomas is evolving. Clinical trials are underway and results are eagerly awaited. Summary: Understanding the role of immune checkpoint inhibitors in combination with other treatment modalities for gliomas is crucial to the improvement of outcomes. The design and conduct of future clinical trials need to account for increasingly complex treatment options.

Original languageEnglish (US)
Article number23
JournalCurrent oncology reports
Volume19
Issue number4
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Keywords

  • Anti-CTLA-4
  • Anti-PD-1
  • Anti-PD-L1
  • Glioblastoma
  • Glioma
  • Immune checkpoint inhibitors

ASJC Scopus subject areas

  • Oncology

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