Immune dysregulation in sepsis

Marcelo Malakooti*, Michael Kelleher, Eric Wald

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The systemic inflammatory response syndrome is a manifestation of the host's immune response to infection. With an aim to eradicate the pathogen, the immune system is activated to encourage a state of inflammation, which is followed by a number of interactions to restore homeostasis. This balance is mediated by a complex interplay among many immune components, which at times can lead to an excessive anti-inflammatory environment, the compensatory anti-inflammatory response syndrome. Numerous cellular and chemokine mediators such as monocytes and granulocyte-macrophage colony-stimulating factor are involved in the manifestation of this syndrome and, if further dysregulated, can lead to immunoparalysis, a prolonged anti-inflammatory environment placing the host at risk for potentially life-threatening infections. Understanding these complex immune reactions may help better identify immune dysregulation during sepsis, holding important implications for the clinician when managing septic patients.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalClinical Pediatric Emergency Medicine
Issue number2
StatePublished - Jun 2014


  • Compensatory anti-inflammatory response syndrome (CARS)
  • Immune system
  • Immunoparalysis
  • Sepsis
  • Systemic inflammatory response syndrome (SIRS)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine


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