Immune impairment and metastatic tumor growth. The need for an immunorestorative drug as an adjunct to surgery

Joel Lundy; Edmund J. Lovett; Steven M. Wolinsky; Philip Conran

doi:10.1002/1097-0142(197903)43:3<945::AID-CNCR2820430324>3.0.CO;2-V

Immune impairment and metastatic tumor growth. The need for an immunorestorative drug as an adjunct to surgery

Joel Lundy^*, Edmund J. Lovett, Steven M. Wolinsky, Philip Conran

^*Corresponding author for this work

Medicine, Infectious Diseases Division

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Abstract

A spontaneous murine metastatic tumor system was used as a model to assess the effects of a major surgical procedure on tumor‐specific immune reactivity and the growth of micrometastases. Any major surgical procedure resulted in impaired cell‐mediated cytotoxicity postoperatively and an increase in the number of gross pulmonary metastases. The use of an immunorestorative drug, Thiabendazole, in the perioperative period resulted in an improved cytotoxic response and a significant decrease in pulmonary metastases. Perioperative immunotherapy can be an effective adjunct to surgery in preventing the growth of micrometastatic foci. Cancer 43:945–951, 1979.

Original language	English (US)
Pages (from-to)	945-951
Number of pages	7
Journal	Cancer
Volume	43
Issue number	3
DOIs	https://doi.org/10.1002/1097-0142(197903)43:3<945::AID-CNCR2820430324>3.0.CO;2-V
State	Published - Mar 1979

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(197903)43:3<945::AID-CNCR2820430324>3.0.CO;2-V

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AB - A spontaneous murine metastatic tumor system was used as a model to assess the effects of a major surgical procedure on tumor‐specific immune reactivity and the growth of micrometastases. Any major surgical procedure resulted in impaired cell‐mediated cytotoxicity postoperatively and an increase in the number of gross pulmonary metastases. The use of an immunorestorative drug, Thiabendazole, in the perioperative period resulted in an improved cytotoxic response and a significant decrease in pulmonary metastases. Perioperative immunotherapy can be an effective adjunct to surgery in preventing the growth of micrometastatic foci. Cancer 43:945–951, 1979.

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Immune impairment and metastatic tumor growth. The need for an immunorestorative drug as an adjunct to surgery

Abstract

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