Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells

Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Mindy Tsai, Stephen J. Galli, Hans C. Oettgen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations


Contact sensitivity responses require both effective immune sensitization following cutaneous exposure to chemical haptens and antigen-specific elicitation of inflammation upon subsequent hapten challenge. We have observed that that antigen-independent effects of immunoglobulin E (IgE) antibodies promote immune sensitization to haptens in the skin. Contact sensitivity is markedly impaired in IgE-/- mice but can be restored by either transfer of sensitized cells from wild-type mice or administration of hapten-irrelevant IgE before sensitization. Moreover, IgE-/- mice exhibit impairment in the emigration of dendritic cells from the epidermis after hapten exposure. Monomeric IgE has been reported to influence mast cell function. We observe diminished contact sensitivity in mice lacking FcεRI or mast cells, and mRNA for several mast cell-associated genes is reduced in IgE-/- vs. wild-type skin after hapten exposure. We propose that levels of IgE normally present in mice favour immune sensitization via antigen-independent effects on mast cells.

Original languageEnglish (US)
Title of host publicationMast Cells and Basophils
Subtitle of host publicationDevelopment, Activation and Roles in Allergic/Autoimmune Disease
Number of pages10
StatePublished - 2005

Publication series

NameNovartis Foundation Symposium
ISSN (Print)1528-2511

ASJC Scopus subject areas

  • Medicine(all)


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