Immune Tolerance for Autoimmune Disease and Cell Transplantation

Xunrong Luo, Stephen D. Miller, Lonnie D. Shea

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve nonspecific immunosuppression that may prevent the appropriate response to an antigen, thereby decreasing humoral immunity and increasing the risks of patient susceptibility to opportunistic infections, viral reactivation, and neoplasia. The induction of antigen-specific immunological tolerance to block undesired immune responses to self- or allogeneic antigens, while maintaining the integrity of the remaining immune system, has the potential to transform the current treatment of autoimmune disease and serve as a key enabling technology for therapies based on cell transplantation.

Original languageEnglish (US)
Pages (from-to)181-205
Number of pages25
JournalAnnual Review of Biomedical Engineering
Volume18
DOIs
StatePublished - Jul 11 2016

Keywords

  • Cell therapies
  • Immunomodulation
  • Inverse vaccines
  • Nanotechnology
  • Tolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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