Immunization against an IL-6 peptide induces anti-IL-6 antibodies and modulates the Delayed-Type Hypersensitivity reaction in cynomolgus monkeys

Lucille Desallais, Caroline Bouchez, Hadley Mouhsine, Gabriel Moreau, Rojo Ratsimandresy, Matthieu Montes, Hervé Do, Françoise Quintin-Colonna, Jean François Zagury*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an innovative anti-IL-6 strategy using a peptide-based active immunization. This approach has previously shown its efficacy in a mouse model of systemic sclerosis. Here the safety, immunogenicity, and efficacy of this strategy was assessed in non human primates. No unscheduled death and clinical signs of toxicity was observed during the study. Furthermore, the cynomolgus monkeys immunized against the IL-6 peptide produced high levels of anti-IL-6 antibodies as well as neutralizing antibodies compared to control groups. They also showed an important decrease of the cumulative inflammatory score following a delayed-type hypersensitivity reaction induced by the Tetanus vaccine compared to control groups (minus 57,9%, P = 0.014). These findings are highly significant because the immunizing IL-6 peptide used in this study is identical in humans and in monkeys and this novel anti-IL-6 strategy could thus represent a promising alternative to monoclonal antibodies.

Original languageEnglish (US)
Article number19549
JournalScientific reports
Volume6
DOIs
StatePublished - Jan 19 2016

ASJC Scopus subject areas

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    Desallais, L., Bouchez, C., Mouhsine, H., Moreau, G., Ratsimandresy, R., Montes, M., Do, H., Quintin-Colonna, F., & Zagury, J. F. (2016). Immunization against an IL-6 peptide induces anti-IL-6 antibodies and modulates the Delayed-Type Hypersensitivity reaction in cynomolgus monkeys. Scientific reports, 6, [19549]. https://doi.org/10.1038/srep19549