Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures

Ryan M. Hickey; Laura M. Kulik; Halla Nimeiri; Aparna Kalyan; Sheetal Kircher; Kush Desai; Ahsun Riaz; Robert J. Lewandowski; Riad Salem

doi:10.1016/j.jvir.2017.07.018

Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures

Ryan M. Hickey^*, Laura M. Kulik, Halla Nimeiri, Aparna Kalyan, Sheetal Kircher, Kush Desai, Ahsun Riaz, Robert J. Lewandowski, Riad Salem

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.

Original language	English (US)
Pages (from-to)	1487-1494
Number of pages	8
Journal	Journal of Vascular and Interventional Radiology
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/j.jvir.2017.07.018
State	Published - Nov 2017

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jvir.2017.07.018

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Hickey, R. M., Kulik, L. M., Nimeiri, H., Kalyan, A., Kircher, S., Desai, K., Riaz, A., Lewandowski, R. J., & Salem, R. (2017). Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures. Journal of Vascular and Interventional Radiology, 28(11), 1487-1494. https://doi.org/10.1016/j.jvir.2017.07.018

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title = "Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures",

abstract = "Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.",

author = "Hickey, {Ryan M.} and Kulik, {Laura M.} and Halla Nimeiri and Aparna Kalyan and Sheetal Kircher and Kush Desai and Ahsun Riaz and Lewandowski, {Robert J.} and Riad Salem",

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year = "2017",

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doi = "10.1016/j.jvir.2017.07.018",

language = "English (US)",

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Hickey, RM, Kulik, LM, Nimeiri, H, Kalyan, A , Kircher, S , Desai, K , Riaz, A , Lewandowski, RJ & Salem, R 2017, 'Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures', Journal of Vascular and Interventional Radiology, vol. 28, no. 11, pp. 1487-1494. https://doi.org/10.1016/j.jvir.2017.07.018

Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures. / Hickey, Ryan M.; Kulik, Laura M.; Nimeiri, Halla et al.
In: Journal of Vascular and Interventional Radiology, Vol. 28, No. 11, 11.2017, p. 1487-1494.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Immuno-oncology and Its Opportunities for Interventional Radiologists

T2 - Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures

AU - Hickey, Ryan M.

AU - Kulik, Laura M.

AU - Nimeiri, Halla

AU - Kalyan, Aparna

AU - Kircher, Sheetal

AU - Desai, Kush

AU - Riaz, Ahsun

AU - Lewandowski, Robert J.

AU - Salem, Riad

PY - 2017/11

Y1 - 2017/11

N2 - Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.

AB - Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.

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SN - 1051-0443

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SP - 1487

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JO - Journal of Vascular and Interventional Radiology

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Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures

Abstract

ASJC Scopus subject areas

UN SDGs

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