Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures

Ryan M. Hickey*, Laura M Kulik, Halla S Nimeiri, Aparna Kalyan, Sheetal Mehta Kircher, Kush R Desai, Ahsun Riaz, Robert J Lewandowski, Riad Salem

*Corresponding author for this work

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.

Original languageEnglish (US)
Pages (from-to)1487-1494
Number of pages8
JournalJournal of Vascular and Interventional Radiology
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2017

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Interventional Radiology
Allergy and Immunology
Immunotherapy
Neoplasms
Therapeutics
Radiologists
Clinical Studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures",
abstract = "Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.",
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T2 - Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures

AU - Hickey, Ryan M.

AU - Kulik, Laura M

AU - Nimeiri, Halla S

AU - Kalyan, Aparna

AU - Kircher, Sheetal Mehta

AU - Desai, Kush R

AU - Riaz, Ahsun

AU - Lewandowski, Robert J

AU - Salem, Riad

PY - 2017/11/1

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AB - Immunotherapy, specifically the use of immune checkpoint inhibitors, offers a new approach to fighting cancer. Although the results of treatment with immune checkpoint inhibition alone have been remarkable for certain cancers, these results are not universal. Preclinical and early clinical studies indicate the potential for synergistic effects when immune checkpoint inhibition is combined with immunogenic local therapies such as ablation and embolization. This review offers an overview of immunology as it relates to immune checkpoint inhibition and the possibilities for synergy when combined with interventional radiology treatments.

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