Immuno- reactive and bioactive corticotropin- releasing factor in rat thymus

Eva Redei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Immunorective corticotropin-releasing factor (CRF) was identified and measured by radioimmunossay in rat thymic extract. Serial dilutions of thymic extract paralleled hypothalamic extract and synthetic CRF standard curves. CRF extracted from rat thymus eluted in the position of synthetic rat CRF on Sephadex G-25 column. Thymus-derived CRF was biologically active as demonstrated by stimulating adrenocorticotropic hormone secretion in dispersed rat anterior pituitary cells. These findings indicate the presence of authentic CRF in rat thymus, further supporting the concept of an integrated regulation of the neuroendocrine-immune responses to environmental stimuli.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalNeuroendocrinology
Volume55
Issue number1
DOIs
StatePublished - Jan 1 1992

Keywords

  • Adrenalectomy
  • Biological activity
  • Corticotropin-releasing factor
  • Corticotropin-releasing factor
  • Immunoactivity
  • Ovariectomy
  • Rat thymus

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

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