Immunoadsorption model for a novel fluidized-bed blood detoxification device

Eric A. Grovender, Charles L. Cooney, Robert Langer, Guillermo Antonio Ameer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A multicompartment Taylor-Couette flow hemofilter was designed to remove toxins from a patient's bloodstream via immunoadsorption. This device (Vortex Flow Plasmapheretic Reactor, VFPR) treats blood plasma with a fluidized-bed of small (45-165 × 10-6 m diameter) particles, while protecting fragile blood cells from lysis. The potential application for the VFPR is dialysis-related amyloidosis, a disease associated with the systemic accumulation of beta-2-microglobulin in patients with long-term kidney failure. The equilibrium behavior of immunoadsorptive gel beads is characterized experimentally and theoretically using confocal microscopy and the Langmuir adsorption isotherm. The importance of external mass-transfer resistance within the active compartment is assessed through dissolution studies conducted with benzoic acid particles. These results are combined with mass-transfer fundamentals to develop a dynamic immunoadsorption model. The modeling results, without the use of adjustable parameters, agree with the experimental data and provide a foundation for further development and eventual application.

Original languageEnglish (US)
Pages (from-to)2357-2365
Number of pages9
JournalAICHE Journal
Volume48
Issue number10
DOIs
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • Chemical Engineering(all)

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