Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review

Shreya Budhiraja, Hinda Najem, Shashwat Tripathi, Nitin R. Wadhawani, Craig Horbinski, Matthew McCord, Alicia C. Lenzen, Amy B. Heimberger, Michael DeCuypere*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.

Original languageEnglish (US)
Article number3655
JournalCancers
Volume15
Issue number14
DOIs
StatePublished - Jul 2023

Keywords

  • immunotherapy
  • microenvironment
  • pediatric brain tumor
  • therapeutic strategies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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