Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review

Shreya Budhiraja; Hinda Najem; Shashwat Tripathi; Nitin R. Wadhawani; Craig Horbinski; Matthew McCord; Alicia C. Lenzen; Amy B. Heimberger; Michael DeCuypere

doi:10.3390/cancers15143655

Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review

Shreya Budhiraja, Hinda Najem, Shashwat Tripathi, Nitin R. Wadhawani, Craig Horbinski, Matthew McCord, Alicia C. Lenzen, Amy B. Heimberger, Michael DeCuypere^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.

Original language	English (US)
Article number	3655
Journal	Cancers
Volume	15
Issue number	14
DOIs	https://doi.org/10.3390/cancers15143655
State	Published - Jul 2023

Keywords

immunotherapy
microenvironment
pediatric brain tumor
therapeutic strategies

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers15143655

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title = "Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review",

abstract = "Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.",

keywords = "immunotherapy, microenvironment, pediatric brain tumor, therapeutic strategies",

author = "Shreya Budhiraja and Hinda Najem and Shashwat Tripathi and Wadhawani, {Nitin R.} and Craig Horbinski and Matthew McCord and Lenzen, {Alicia C.} and Heimberger, {Amy B.} and Michael DeCuypere",

note = "Funding Information: This study was funded by the NIH grants CA120813, NS120547, and P30CA060553, P50CA221747, the Remission Alliance, and gracious funding from the Malnati Brain Tumor Institute. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jul,

doi = "10.3390/cancers15143655",

language = "English (US)",

volume = "15",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "14",

}

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T1 - Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment

T2 - A Scoping Review

AU - Budhiraja, Shreya

AU - Najem, Hinda

AU - Tripathi, Shashwat

AU - Wadhawani, Nitin R.

AU - Horbinski, Craig

AU - McCord, Matthew

AU - Lenzen, Alicia C.

AU - Heimberger, Amy B.

AU - DeCuypere, Michael

N1 - Funding Information: This study was funded by the NIH grants CA120813, NS120547, and P30CA060553, P50CA221747, the Remission Alliance, and gracious funding from the Malnati Brain Tumor Institute. Publisher Copyright: © 2023 by the authors.

PY - 2023/7

Y1 - 2023/7

N2 - Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.

AB - Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.

KW - immunotherapy

KW - microenvironment

KW - pediatric brain tumor

KW - therapeutic strategies

UR - http://www.scopus.com/inward/record.url?scp=85167856610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85167856610&partnerID=8YFLogxK

U2 - 10.3390/cancers15143655

DO - 10.3390/cancers15143655

M3 - Review article

C2 - 37509316

AN - SCOPUS:85167856610

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 14

M1 - 3655

ER -

Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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