Abstract
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients. In vivo murine models of glioma provide an invaluable resource to achieving that end, and their use is an essential part of the preclinical workup for novel therapeutics that need to be tested in animal models prior to testing experimental therapies in patients. In this article, we review five contemporary immunocompetent mouse models, GL261 (C57BL/6), GL26 (C57BL/6) CT-2A (C57BL/6), SMA-560 (VM/Dk), and 4C8 (B6D2F1), each of which offer a suitable platform for testing novel immunotherapeutic approaches.
| Original language | English (US) |
|---|---|
| Article number | 107 |
| Journal | Journal of Translational Medicine |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 29 2014 |
Funding
Dr. Ivan is funded by the National Research Education Foundation through the American Association of Neurological Surgeons. M.Z. Sun and E.T. Sayegh are Howard Hughes Medical Institute Medical Research Fellows. M. Safaee was supported by a grant from the Doris Duke Charitable Foundation. This work was supported by the Reza and Georgianna Khatib Endowed Chair in Skull Base Tumor Surgery at UCSF, and the Michael J. Marchese Professor and Chair at Northwestern University.
Keywords
- Animal models
- Astrocytoma
- Glioblastoma
- Glioma
- Immune response
- Immunosuppression
- Immunotherapy
- Murine
- Preclinical
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
