Immunoconglutinin and complement studies in congenital nephrotic syndrome and nephritis of henoch - Schönlein purpura in children

S. T. Shulman, T. M. Barratt*, J. F. Soothill

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Evidence of complement activation in 6 children with congenital nephrotic syndrome and 9 children with nephritis associated with Henoch-Schönlein purpura was sought by estimating the concentration and by immunoelectrophoretic analysis of the complement component C3, and by immunoconglutinin titration (IK: an autoantibody to reacted complement components). IK and quantitative C3 levels did not differ significantly from control values in either disease; in vivo C3 conversion was not detected in plasma from congenital nephrotic patients, but was present in 2 of 9 patients with Henoch-Schönlein nephritis. The data do not provide consistent evidence of complement involvement in either disease.

Original languageEnglish (US)
Pages (from-to)838-841
Number of pages4
JournalArchives of disease in childhood
Volume46
Issue number250
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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