Immunocytochemical detection of carcinoembryonic antigen in fine‐needle aspirates from patients with diverse breast diseases

Borislav A. Alexiev*, Ivan N. Valkov, Alexander A. Popov, Vasil S. Marinov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Fine‐needle aspirates and paraffin‐embedded tissue sections from 91 cases with diverse breast diseases were immunostained with carcinoembryonic antigen (CEA) monoclonal antibody using a BioGenex StrAviGen kit based on the biotin‐streptavidin amplified methodology. The results were compared with histopathologic tumor type and tumor stage. CEA was not expressed in fibrocystic changes with mild or florid epithelial hyperplasia (n = 23) and fibroadenomas (n = 8). On the other hand, 90% (56/60) of primary breast carcinomas showed positive cytoplasmic staining for CEA. No correlation was found between CEA expression, histopathologic tumor type, and tumor stage. We suggest that CEA immunocytochemistry will help in the accurate diagnosis of primary breast carcinoma in fine‐needle aspirates in addition to the usual cytological criteria.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalDiagnostic Cytopathology
Volume9
Issue number4
DOIs
StatePublished - Jan 1 1993

Keywords

  • Breast
  • CEA
  • Fine‐needle aspirates
  • Immunocytochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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