Immunocytochemical localization of liver-specific proteins in pancreatic hepatocytes of rat.

N. Usuda*, J. K. Reddy, T. Hashimoto, M. S. Rao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Hepatocytes are induced in the pancreas of rats maintained first on a copper-deficient diet for 8 weeks and then on normal rat chow. These cells are morphologically identical to parenchymal cells of the liver. These hepatocytes contain two liver-specific proteins: carbamyl phosphate synthetase I, a mitochondrial matrix protein that participates in the conversion of ammonia to carbamyl phosphate; and urate oxidase, an enzyme that catalyzes the oxidation of uric acid to allantoin. In addition, we also present evidence indicating that dietary administration of ciprofibrate induces peroxisomal beta-oxidation pathway enzymes, while the levels of catalase are unaltered in pancreatic hepatocytes. These observations along with the previously published results further establish the identity of pancreatic hepatocytes to parenchymal cells of liver and clearly indicate that transdifferentiation of pancreatic cells to hepatocytes is associated with activation of several liver-specific genes.

Original languageEnglish (US)
Pages (from-to)299-306
Number of pages8
JournalEuropean journal of cell biology
Issue number2
StatePublished - Jun 1988

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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