Abstract
Recently, a complete bidirectional circuit between the immune and neuroendocrine systems has been documented. Previous reports from this laboratory have shown that there are complex reciprocal relationships between immune and hypothalamic-pituitary-adrenal (HPA)-axis function in major depression. To further examine the immune-endocrine relationships, this study investigates plasma baseline cortisol and prolactin secretion in relation to plasma interleukin-6 (IL-6) and soluble IL-2 receptor (sIL-2R) levels in 34 healthy controls and 56 major depressed patients. There were significant positive correlations between IL-6 or sIL-2R and plasma cortisol in major depressed subjects and in the combined group of major depressed and healthy subjects. There were also significant positive correlations between plasma prolactin and sIL-2R concentrations in major depressed subjects and in the combined groups of normal and major depressed subjects.
Original language | English (US) |
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Pages (from-to) | 172-178 |
Number of pages | 7 |
Journal | European Archives of Psychiatry and Clinical Neuroscience |
Volume | 245 |
Issue number | 3 |
DOIs | |
State | Published - May 1995 |
Keywords
- Cortisol
- Depression
- Interleukin-6
- Pituitary
- Prolactin
- Psychoimmunology
- Soluble interleukin-2 receptor
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Pharmacology (medical)