Immunoendocrine aspects of major depression - Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol

Michael Maes*, Eugène Bosmans, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Recently, a complete bidirectional circuit between the immune and neuroendocrine systems has been documented. Previous reports from this laboratory have shown that there are complex reciprocal relationships between immune and hypothalamic-pituitary-adrenal (HPA)-axis function in major depression. To further examine the immune-endocrine relationships, this study investigates plasma baseline cortisol and prolactin secretion in relation to plasma interleukin-6 (IL-6) and soluble IL-2 receptor (sIL-2R) levels in 34 healthy controls and 56 major depressed patients. There were significant positive correlations between IL-6 or sIL-2R and plasma cortisol in major depressed subjects and in the combined group of major depressed and healthy subjects. There were also significant positive correlations between plasma prolactin and sIL-2R concentrations in major depressed subjects and in the combined groups of normal and major depressed subjects.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume245
Issue number3
DOIs
StatePublished - May 1995

Keywords

  • Cortisol
  • Depression
  • Interleukin-6
  • Pituitary
  • Prolactin
  • Psychoimmunology
  • Soluble interleukin-2 receptor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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