Immunogenetics, resistance, and susceptibility to theiler's virus infection

Roger W. Melvold*, Stephen D. Miller

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The genetic basis for differential susceptibility to Theiler's virus-induced demyelinating disease is complex and often confusing, similar to the situation seen in analyzing the genetic risk for human multiple sclerosis. Numerous genetic loci have been identified as influencing the likelihood of disease development, most prominently among them the class I H2-D locus which has the single most important effect of any of the loci studied thus far. Genetic analysis is complicated, however, by the fact that susceptibility to the disease is not inherited as a consistently dominant or recessive trait, and that the relevant loci can differ from one mouse strain to another. The system has proved amenable to the utilization of numerous transgenic and knock-out gene systems to analyze the disease process.

Original languageEnglish (US)
Title of host publicationExperimental Models of Multiple Sclerosis
PublisherSpringer US
Number of pages16
ISBN (Electronic)9780387255187
ISBN (Print)0387255176, 9780387255170
StatePublished - Jan 1 2005


  • H2
  • H2-D
  • Theiler's murine encephalomyelitis virus (TMEV)
  • demyelinating disease
  • genetics
  • major histocompatibility complex (MHC)
  • multiple sclerosis

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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