Abstract
We evaluated the immunogenicity and safety of three 40 μg doses of hepatitis B vaccine in oncology patients receiving chemotherapy. Of 76 patients screened for entry into the study, 13 (17%) already had been exposed to hepatitis B and were ineligible; 26 chose to join the study. The cumulative life-table response rate during the 12-month observation period was 70.8%; adequate immune response was linked to survival, 73% in survivors completing the study and 9% in nonsurvivors. Adverse effects were minor. We conclude that hepatitis B vaccine is safe and usually effective in inducing immunity in oncology patients younger than 60 years of age who are receiving chemotherapy.
Original language | English (US) |
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Pages (from-to) | 718-722 |
Number of pages | 5 |
Journal | Journal of Clinical Oncology |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 1985 |
ASJC Scopus subject areas
- Oncology
- Cancer Research