TY - JOUR
T1 - Immunoglobulin allotypic markers in Kawasaki disease
AU - Shulman, Stanford T.
AU - Melish, Marian
AU - Inoue, Osmu
AU - Kato, Hirohisa
AU - Tomita, Shobun
PY - 1993/1
Y1 - 1993/1
N2 - We investigated the possible relationship of the distribution of immunoglobulin allotypic markers for susceptibility to Kawasaki disease in Japanese, Japanese-American, and white American populations. The kappa-chain allotype Km1 was present in 25.6% of sera from white patients with Kawasaki disease and in 14.4% of control sera (p<0.01), and the combination of Km1 with Gm heterozygosity was present in 17.9% of white patients with Kawasaki disease and in 6.4% of control sera (p<0.0001). In all populations studied, differences were observed between the patients with Kawasaki disease and the race-matched control subjects. The findings support the hypothesis that one or more unknown infectious agents may trigger genetically influenced immune responses that result in clinically recognizable Kawasaki disease.
AB - We investigated the possible relationship of the distribution of immunoglobulin allotypic markers for susceptibility to Kawasaki disease in Japanese, Japanese-American, and white American populations. The kappa-chain allotype Km1 was present in 25.6% of sera from white patients with Kawasaki disease and in 14.4% of control sera (p<0.01), and the combination of Km1 with Gm heterozygosity was present in 17.9% of white patients with Kawasaki disease and in 6.4% of control sera (p<0.0001). In all populations studied, differences were observed between the patients with Kawasaki disease and the race-matched control subjects. The findings support the hypothesis that one or more unknown infectious agents may trigger genetically influenced immune responses that result in clinically recognizable Kawasaki disease.
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U2 - 10.1016/S0022-3476(05)83493-6
DO - 10.1016/S0022-3476(05)83493-6
M3 - Article
C2 - 8419619
AN - SCOPUS:0027525905
SN - 0022-3476
VL - 122
SP - 84
EP - 86
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 1
ER -