Immunhistochemische und elektronenmikroskopische Untersuchung der Myoepithelien bei Mastopathien und Karzinomen der Milchdrüse.

Translated title of the contribution: Immunohistochemical and electron microscopical study of the myoepithelium in mastopathy and carcinoma of the mammary gland

B. Alexiev*, Z. Michova, I. Michailov, R. Takov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Biopsies obtained from 45 cases of invasive ductal carcinoma and 41 cases of cystic mastopathy were immunohistochemically investigated, with electron microscopy being used on some of them, for the purpose of clearing up presence, distribution, and ultrastructural peculiarities of the myoepithelial cells. Focal or diffuse myoepithelial proliferations were observed in all cases of cystic mastopathy, with peripheral layers of myoepithelium at the basal membrane being widely preserved. Myoepithelial cells had lost their normal position and cellular orientation in the regions with intraductal carcinoma. Actin-positive, high-microfilament myoepithelial cells were frequent findings recorded from parenchyma in cases of invasive ductal carcinoma without specific differentiation, though cells of that kind were rarely detectable from parenchyma in cases of medullary carcinoma. Particular attention should be given to the presence of tumor cells differing from each other for their morphological and functional differentiation in cases of carcinoma of the mammary gland.

Translated title of the contributionImmunohistochemical and electron microscopical study of the myoepithelium in mastopathy and carcinoma of the mammary gland
Original languageGerman
Pages (from-to)427-438
Number of pages12
JournalZentralblatt fur Allgemeine Pathologie und Pathologische Anatomie
Volume136
Issue number5
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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