Immunohistochemical detection of the β4 integrin subunit im pancreatic adenocarcinoma

Brianna Gleason; Brian Adley; M. Sambasiva Rao; Leslie K. Diaz

doi:10.1369/jhc.4B6522.2005

Immunohistochemical detection of the β4 integrin subunit im pancreatic adenocarcinoma

Brianna Gleason, Brian Adley, M. Sambasiva Rao, Leslie K. Diaz^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The expression of the β4 integrin subunit protein in pancreatic cancer was investigated using routine immunohistochemical methods on paraffin-embedded archival material. Forty-eight cases of pancreatic ductal adenocarcinoma were immunostained with a monoclonal antibody to the β4 integrin subunit, and the extent of staining was compared with that seen in non-cancerous pancreatic tissues, including 15 separate cases of chronic pancreatitis and 6 sections from normal pancreas. We found that the β4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.

Original language	English (US)
Pages (from-to)	799-801
Number of pages	3
Journal	Journal of Histochemistry and Cytochemistry
Volume	53
Issue number	6
DOIs	https://doi.org/10.1369/jhc.4B6522.2005
State	Published - Jun 2005

Keywords

Immunohistochemistry
Pancreatic cancer
α6β4 integrin

ASJC Scopus subject areas

Anatomy
Histology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1369/jhc.4B6522.2005

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title = "Immunohistochemical detection of the β4 integrin subunit im pancreatic adenocarcinoma",

abstract = "The expression of the β4 integrin subunit protein in pancreatic cancer was investigated using routine immunohistochemical methods on paraffin-embedded archival material. Forty-eight cases of pancreatic ductal adenocarcinoma were immunostained with a monoclonal antibody to the β4 integrin subunit, and the extent of staining was compared with that seen in non-cancerous pancreatic tissues, including 15 separate cases of chronic pancreatitis and 6 sections from normal pancreas. We found that the β4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.",

keywords = "Immunohistochemistry, Pancreatic cancer, α6β4 integrin",

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AU - Gleason, Brianna

AU - Adley, Brian

AU - Rao, M. Sambasiva

AU - Diaz, Leslie K.

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Y1 - 2005/6

N2 - The expression of the β4 integrin subunit protein in pancreatic cancer was investigated using routine immunohistochemical methods on paraffin-embedded archival material. Forty-eight cases of pancreatic ductal adenocarcinoma were immunostained with a monoclonal antibody to the β4 integrin subunit, and the extent of staining was compared with that seen in non-cancerous pancreatic tissues, including 15 separate cases of chronic pancreatitis and 6 sections from normal pancreas. We found that the β4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.

AB - The expression of the β4 integrin subunit protein in pancreatic cancer was investigated using routine immunohistochemical methods on paraffin-embedded archival material. Forty-eight cases of pancreatic ductal adenocarcinoma were immunostained with a monoclonal antibody to the β4 integrin subunit, and the extent of staining was compared with that seen in non-cancerous pancreatic tissues, including 15 separate cases of chronic pancreatitis and 6 sections from normal pancreas. We found that the β4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.

KW - Immunohistochemistry

KW - Pancreatic cancer

KW - α6β4 integrin

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JF - Journal of Histochemistry and Cytochemistry

IS - 6

ER -

Immunohistochemical detection of the β4 integrin subunit im pancreatic adenocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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