Immunohistochemical diagnosis of Cryptococcus neoformans var. gattii infection in chronic meningoencephalitis: The first case in Japan

Taiji Tsunemi*, Tomoyuki Kamata, Yuichi Fumimura, Mutsufusa Watanabe, Masanaga Yamawaki, Yukinobu Saito, Takashi Kanda, Kenichi Ohashi, Nobuo Suegara, Somei Murayama, Koichi Makimura, Hideyo Yamaguchi, Hidehiro Mizusawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Cryptococcus neoformans (C. neoformans) var. gattii infection usually occurs in tropical and subtropical areas, and rarely in the northern hemisphere. We report the first Japanese with cryptococcal meningoencephalitis caused by C. neoformans var. gattii infection that occurred during a trip to Australia. This agent was identified in a cerebellar biopsy specimen by immunohistochemical technique with serotype-specific anti-sera. Because the meningitis caused by it did not respond well to conventional therapy, we used an aggressive therapeutic regimen to successfully treat the patient. Even in areas where C. neoformans var. gattii does not exist, this infection should be considered possible as a travel-related infection.

Original languageEnglish (US)
Pages (from-to)1241-1244
Number of pages4
JournalInternal Medicine
Volume40
Issue number12
DOIs
StatePublished - 2001

Keywords

  • Cerebellar biopsy
  • Serotype-specific anti-sera
  • Travel-related infection

ASJC Scopus subject areas

  • Internal Medicine

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