Immunohistochemical localization of cytokeratin 17 in transitional cell carcinomas of the human urinary tract

Vita I. Guelstein, Tamara A. Tchipysheva, Valeria D. Ermilova, Sergey M. Troyanovsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The expression of cytokeratin (CK) 17 was studied in 28 primary transitional cell carcinomas (TCCs) of the human urinary tract using CK 17-specific monoclonal antibody E3. While CK 17 was not detectable at all or only present in some areas of basal cells in normal-appearing urothelium, a certain subpopulation of cells of all G1 and G1/G2 TCCs examined (9 cases) stained positive for CK 17. These latter cells were either restricted to the basal compartment or located also in suprabasal layers exhibiting a decreasing intensity of immunoreactivity. CK 17 was seen in practically all cells in G2 and G2/G3 tumors (7 cases). In contrast, G3 TCCs and anaplastic carcinomas showed a highly variable CK 17 staining pattern ranging from completely negative to completely positive with several intermediate phenotypes. Our results indicate that CK 17 could be a useful marker for the progression of urinary tumors.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalVirchows Archiv B
Volume64
Issue number1
DOIs
StatePublished - Dec 1 1993

Keywords

  • Bladder cancer
  • Cytokeratins
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Immunohistochemical localization of cytokeratin 17 in transitional cell carcinomas of the human urinary tract'. Together they form a unique fingerprint.

Cite this