TY - JOUR
T1 - Immunohistochemical observations on spinal tissue innervation
T2 - A review of hypothetical mechanisms of back pain
AU - Grönblad, Mats
AU - Weinstein, James Neil
AU - Santavirta, Seppo
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - Immunohistochemical studies support earlier reports of a rich nerve supply to the posterior longitudinal ligament, a less developed innervation of the anterior ligament and the outermost annular ring, and a total lack of innervation in deeper parts of the intervertebral disc. Whether this pattern of innervation is altered when the disc becomes severely degenerated is presently uncertain. Recent studies have also revealed neuropeptide-immunoreactive nerves in the outermost parts of the annulus and adjacent peridiscal ligaments. These nerves are probably involved in discogenic back pain, and may become sensitized when disc tissue is injured. This sensitization appears to be coupled to an alteration of neuropeptide pools in the nearby dorsal root ganglion, the important site of neuropeptide production. Direct influences on the dorsal root ganglion, mechanical and/or chemical, may also be important, and may be involved in spinal segment degeneration.
AB - Immunohistochemical studies support earlier reports of a rich nerve supply to the posterior longitudinal ligament, a less developed innervation of the anterior ligament and the outermost annular ring, and a total lack of innervation in deeper parts of the intervertebral disc. Whether this pattern of innervation is altered when the disc becomes severely degenerated is presently uncertain. Recent studies have also revealed neuropeptide-immunoreactive nerves in the outermost parts of the annulus and adjacent peridiscal ligaments. These nerves are probably involved in discogenic back pain, and may become sensitized when disc tissue is injured. This sensitization appears to be coupled to an alteration of neuropeptide pools in the nearby dorsal root ganglion, the important site of neuropeptide production. Direct influences on the dorsal root ganglion, mechanical and/or chemical, may also be important, and may be involved in spinal segment degeneration.
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U2 - 10.3109/17453679108994512
DO - 10.3109/17453679108994512
M3 - Review article
C2 - 1837417
AN - SCOPUS:0026410084
VL - 62
SP - 614
EP - 622
JO - Acta Orthopaedica
JF - Acta Orthopaedica
SN - 1745-3674
IS - 6
ER -