Immunoisolating pancreatic islets by encapsulation with selective withdrawal

Jason L. Wyman; Seda Kizilel; Ryan Skarbek; Xiangyang Zhao; Matthew Connors; William S. Dillmore; William L. Murphy; Milan Mrksich; Sidney R. Nagel; Marc R. Garfinkel

doi:10.1002/smll.200600231

Immunoisolating pancreatic islets by encapsulation with selective withdrawal

Jason L. Wyman^*, Seda Kizilel, Ryan Skarbek, Xiangyang Zhao, Matthew Connors, William S. Dillmore, William L. Murphy, Milan Mrksich, Sidney R. Nagel, Marc R. Garfinkel

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

This manuscript reports the application of the selective-withdrawal coating technique to the microencapsulation of insulin-producing pancreatic islets within thin poly (ethylene glycol) coatings. These polymer coatings permit the islets to respond to changes in glucose concentration by producing insulin with a dose-response profile that is substantially similar to that of unencapsulated islets. Furthermore, the hydrogel capsules exclude the large molecules of the immune system. These results suggest that the microencapsulation technique - which combines droplet formation from a flow of two immiscible fluids with polymerization chemistries - has the characteristics required for the transplantation of islets for the treatment of Type I diabetes.

Original language	English (US)
Pages (from-to)	683-690
Number of pages	8
Journal	Small
Volume	3
Issue number	4
DOIs	https://doi.org/10.1002/smll.200600231
State	Published - Apr 2007

Keywords

Biomaterials
Coatings
Diabetes
Mesoporous materials
Microcapsules

ASJC Scopus subject areas

General Chemistry
General Materials Science
Biotechnology
Biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smll.200600231

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title = "Immunoisolating pancreatic islets by encapsulation with selective withdrawal",

abstract = "This manuscript reports the application of the selective-withdrawal coating technique to the microencapsulation of insulin-producing pancreatic islets within thin poly (ethylene glycol) coatings. These polymer coatings permit the islets to respond to changes in glucose concentration by producing insulin with a dose-response profile that is substantially similar to that of unencapsulated islets. Furthermore, the hydrogel capsules exclude the large molecules of the immune system. These results suggest that the microencapsulation technique - which combines droplet formation from a flow of two immiscible fluids with polymerization chemistries - has the characteristics required for the transplantation of islets for the treatment of Type I diabetes.",

keywords = "Biomaterials, Coatings, Diabetes, Mesoporous materials, Microcapsules",

author = "Wyman, {Jason L.} and Seda Kizilel and Ryan Skarbek and Xiangyang Zhao and Matthew Connors and Dillmore, {William S.} and Murphy, {William L.} and Milan Mrksich and Nagel, {Sidney R.} and Garfinkel, {Marc R.}",

year = "2007",

month = apr,

doi = "10.1002/smll.200600231",

language = "English (US)",

volume = "3",

pages = "683--690",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

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T1 - Immunoisolating pancreatic islets by encapsulation with selective withdrawal

AU - Wyman, Jason L.

AU - Kizilel, Seda

AU - Skarbek, Ryan

AU - Zhao, Xiangyang

AU - Connors, Matthew

AU - Dillmore, William S.

AU - Murphy, William L.

AU - Mrksich, Milan

AU - Nagel, Sidney R.

AU - Garfinkel, Marc R.

PY - 2007/4

Y1 - 2007/4

N2 - This manuscript reports the application of the selective-withdrawal coating technique to the microencapsulation of insulin-producing pancreatic islets within thin poly (ethylene glycol) coatings. These polymer coatings permit the islets to respond to changes in glucose concentration by producing insulin with a dose-response profile that is substantially similar to that of unencapsulated islets. Furthermore, the hydrogel capsules exclude the large molecules of the immune system. These results suggest that the microencapsulation technique - which combines droplet formation from a flow of two immiscible fluids with polymerization chemistries - has the characteristics required for the transplantation of islets for the treatment of Type I diabetes.

AB - This manuscript reports the application of the selective-withdrawal coating technique to the microencapsulation of insulin-producing pancreatic islets within thin poly (ethylene glycol) coatings. These polymer coatings permit the islets to respond to changes in glucose concentration by producing insulin with a dose-response profile that is substantially similar to that of unencapsulated islets. Furthermore, the hydrogel capsules exclude the large molecules of the immune system. These results suggest that the microencapsulation technique - which combines droplet formation from a flow of two immiscible fluids with polymerization chemistries - has the characteristics required for the transplantation of islets for the treatment of Type I diabetes.

KW - Biomaterials

KW - Coatings

KW - Diabetes

KW - Mesoporous materials

KW - Microcapsules

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DO - 10.1002/smll.200600231

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JO - Small

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Immunoisolating pancreatic islets by encapsulation with selective withdrawal

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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