Immunoisolating pancreatic islets by encapsulation with selective withdrawal

Jason L. Wyman*, Seda Kizilel, Ryan Skarbek, Xiangyang Zhao, Matthew Connors, William S. Dillmore, William L. Murphy, Milan Mrksich, Sidney R. Nagel, Marc R. Garfinkel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

This manuscript reports the application of the selective-withdrawal coating technique to the microencapsulation of insulin-producing pancreatic islets within thin poly (ethylene glycol) coatings. These polymer coatings permit the islets to respond to changes in glucose concentration by producing insulin with a dose-response profile that is substantially similar to that of unencapsulated islets. Furthermore, the hydrogel capsules exclude the large molecules of the immune system. These results suggest that the microencapsulation technique - which combines droplet formation from a flow of two immiscible fluids with polymerization chemistries - has the characteristics required for the transplantation of islets for the treatment of Type I diabetes.

Original languageEnglish (US)
Pages (from-to)683-690
Number of pages8
JournalSmall
Volume3
Issue number4
DOIs
StatePublished - Apr 1 2007

Keywords

  • Biomaterials
  • Coatings
  • Diabetes
  • Mesoporous materials
  • Microcapsules

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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