Immunologic inhibition of ultraviolet radiation-induced tumor suppressor cell activity

Richard D. Granstein*, John A. Parrish, Daniel J. Mcauliffe, Carl Waltenbaugh, Mark I. Greene

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Long-term exposure of C3H mice to ultraviolet radiation resulted in the formation of suppressor T cells that recognize ultraviolet radiation-induced regressor skin cancers as a class before the appearance of overt tumors. Administration of monoclonal antibodies to the product of the I-Jk subregion of the major histocompatibility complex or low doses of cyclophosphamide in vivo inhibited the development or activity of these cells. This activity of the monoclonal antibody was eliminated by adsorption on B10.BR (I-Jk) but not B10.D2 (I-Jd) splenocytes. These findings provide evidence that elements expressing the I-J determinant are important in regulating the host response prior to the overt development of ultraviolet radiation-induced skin cancers and suggest novel therapeutic approaches to malignancies or other diseases involving suppressor T cells in their pathogenesis.

Original languageEnglish (US)
Pages (from-to)615-617
Number of pages3
JournalScience
Volume224
Issue number4649
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • General

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