Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor

Veerappan Muthukkaruppan; Hrishikesh R. Chakkalath; Mathew M. James

doi:10.1016/0165-2478(87)90025-3

Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor

Veerappan Muthukkaruppan^*, Hrishikesh R. Chakkalath, Mathew M. James

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

By using an indirect immunofluorescence technique with OKT₃ and OKT₁₁ monoclonal antibodies, the percentage of CD₂ positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD₃ positive cells were at the normal level. Further, CD₂ positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD₂ and CD₃ receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD₂ but not CD₃ positive cells. Such a modulation of CD₂ on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD₂ modulation and immunologic unresponsiveness in leprosy.

Original language	English (US)
Pages (from-to)	199-204
Number of pages	6
Journal	Immunology Letters
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/0165-2478(87)90025-3
State	Published - Jul 1987

Keywords

E-receptor
Immunofluorescence
Leprosy
Lymphoproliferation
Mycobacterium leprae
Unresponsiveness

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/0165-2478(87)90025-3

Cite this

@article{3a32b2c179544c42a82879ba173b2c10,

title = "Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor",

abstract = "By using an indirect immunofluorescence technique with OKT3 and OKT11 monoclonal antibodies, the percentage of CD2 positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD3 positive cells were at the normal level. Further, CD2 positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD2 and CD3 receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD2 but not CD3 positive cells. Such a modulation of CD2 on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD2 modulation and immunologic unresponsiveness in leprosy.",

keywords = "E-receptor, Immunofluorescence, Leprosy, Lymphoproliferation, Mycobacterium leprae, Unresponsiveness",

author = "Veerappan Muthukkaruppan and Chakkalath, {Hrishikesh R.} and James, {Mathew M.}",

note = "Funding Information: This work was partly supported by Indian Council of Medical Research, New Delhi. Cooperation of Dr. P. Suresh, Mr. John Dalton and the staff of Arogya Agam, Andipatti, Madurai District in providing us with blood samples from leprosy patients is gratefully acknowledged.",

year = "1987",

month = jul,

doi = "10.1016/0165-2478(87)90025-3",

language = "English (US)",

volume = "15",

pages = "199--204",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor

AU - Muthukkaruppan, Veerappan

AU - Chakkalath, Hrishikesh R.

AU - James, Mathew M.

N1 - Funding Information: This work was partly supported by Indian Council of Medical Research, New Delhi. Cooperation of Dr. P. Suresh, Mr. John Dalton and the staff of Arogya Agam, Andipatti, Madurai District in providing us with blood samples from leprosy patients is gratefully acknowledged.

PY - 1987/7

Y1 - 1987/7

N2 - By using an indirect immunofluorescence technique with OKT3 and OKT11 monoclonal antibodies, the percentage of CD2 positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD3 positive cells were at the normal level. Further, CD2 positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD2 and CD3 receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD2 but not CD3 positive cells. Such a modulation of CD2 on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD2 modulation and immunologic unresponsiveness in leprosy.

AB - By using an indirect immunofluorescence technique with OKT3 and OKT11 monoclonal antibodies, the percentage of CD2 positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD3 positive cells were at the normal level. Further, CD2 positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD2 and CD3 receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD2 but not CD3 positive cells. Such a modulation of CD2 on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD2 modulation and immunologic unresponsiveness in leprosy.

KW - E-receptor

KW - Immunofluorescence

KW - Leprosy

KW - Lymphoproliferation

KW - Mycobacterium leprae

KW - Unresponsiveness

UR - http://www.scopus.com/inward/record.url?scp=0023180945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023180945&partnerID=8YFLogxK

U2 - 10.1016/0165-2478(87)90025-3

DO - 10.1016/0165-2478(87)90025-3

M3 - Article

C2 - 3499387

AN - SCOPUS:0023180945

SN - 0165-2478

VL - 15

SP - 199

EP - 204

JO - Immunology Letters

JF - Immunology Letters

IS - 3

ER -

Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this