Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor

Veerappan Muthukkaruppan*, Hrishikesh R. Chakkalath, Mathew M. James

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

By using an indirect immunofluorescence technique with OKT3 and OKT11 monoclonal antibodies, the percentage of CD2 positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD3 positive cells were at the normal level. Further, CD2 positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD2 and CD3 receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD2 but not CD3 positive cells. Such a modulation of CD2 on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD2 modulation and immunologic unresponsiveness in leprosy.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalImmunology Letters
Volume15
Issue number3
DOIs
StatePublished - Jul 1987

Keywords

  • E-receptor
  • Immunofluorescence
  • Leprosy
  • Lymphoproliferation
  • Mycobacterium leprae
  • Unresponsiveness

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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