Immunological and structural homology between human T-cell leukemia virus type I envelope glycoprotein and a region of human interleukin-2 implicated in binding the β receptor

D. S. Kohtz, A. Altman, J. D. Kohtz, S. Puszkin

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The N-terminal segment of human interleukin-2 (hIL-2) appears to mediate binding of the β hIL-2 receptor (R. Robb, C. Rusk, J. Yodoi, and W. Greene, Proc. Natl. Acad. Sci. USA 84:2002-2006, 1987). An affinity-purified antibody prepared against this peptide segment (p81) is shown here to cross-react with a homologous region of the human T-cell leukemia virus type I (HTLV-I) envelope glycoprotein, raising the interesting possibility that the envelope glycoprotein of HTLV-I can interact with the β hIL-2 receptor.

Original languageEnglish (US)
Pages (from-to)659-662
Number of pages4
JournalJournal of virology
Volume62
Issue number2
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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