Immunology of Adverse Drug Reactions

K. W. Witte, D. P. West

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Adverse reactions to drugs often include an immunologic response. An understanding of immunologic mechanisms is useful in understanding the clinical manifestations of drug allergy. Predisposing factors to the development of allergic reactions to drugs include host factors as well as drug factors. Immune response relates to what we know about the components of the immune system as well as their differentiation and maturation processes. Immunologic reactions are often classified as Type I, Type II, Type III or Type IV, and these reaction types often correlate with clinical manifestations. For each reaction type the mechanism, drugs implicated, clinical manifestations, and treatment can be described. 1982 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)54-65
Number of pages12
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Issue number1
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Pharmacology (medical)

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