Immunology of Nasal Polyposis and Allergic Rhinitis

Whitney Stevens*, Kathryn E Hulse

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Allergic rhinitis and chronic rhinosinusitis with nasal polyps (CRSwNP) represent two common diseases associated with significant morbidity and socioeconomic burden. Both of these diseases are characterized by type 2 inflammatory responses, but the mechanisms that drive each of these diseases appear to be distinct. While allergic rhinitis is driven by multiple cycles of classic early- and late-phase allergic responses, CRSwNP is driven by unknown chronic inflammatory mechanisms. Further studies are needed to elucidate the mechanisms that result in the formation of chronic type 2 inflammatory responses versus classic allergic reactions. Importantly, new tools and/or animal models are needed to aid mechanistic studies in CRSwNP, which would help to address many of these questions and ultimately improve patient care and quality of life. This article will focus on the epidemiology and the current understanding of the immunologic mechanisms associated with each of these diseases.

Original languageEnglish (US)
Title of host publicationPhysiology and Immune System Dysfunction
PublisherElsevier Inc
Pages306-312
Number of pages7
Volume5
ISBN (Print)9780080921525
DOIs
StatePublished - Apr 27 2016

Fingerprint

Allergy and Immunology
Nose
Nasal Polyps
Patient Care
Hypersensitivity
Epidemiology
Animal Models
Quality of Life
Morbidity
Allergic Rhinitis

Keywords

  • Allergic rhinitis
  • B cells
  • Chemokines
  • Chronic rhinosinusitis
  • Cytokines
  • Dendritic cells
  • Epithelial cells
  • IgE
  • Mast cells
  • Nasal polyps
  • Sensitization
  • T-helper cells
  • Type 2 inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stevens, W., & Hulse, K. E. (2016). Immunology of Nasal Polyposis and Allergic Rhinitis. In Physiology and Immune System Dysfunction (Vol. 5, pp. 306-312). Elsevier Inc. https://doi.org/10.1016/B978-0-12-374279-7.16006-0
Stevens, Whitney ; Hulse, Kathryn E. / Immunology of Nasal Polyposis and Allergic Rhinitis. Physiology and Immune System Dysfunction. Vol. 5 Elsevier Inc, 2016. pp. 306-312
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Stevens, W & Hulse, KE 2016, Immunology of Nasal Polyposis and Allergic Rhinitis. in Physiology and Immune System Dysfunction. vol. 5, Elsevier Inc, pp. 306-312. https://doi.org/10.1016/B978-0-12-374279-7.16006-0

Immunology of Nasal Polyposis and Allergic Rhinitis. / Stevens, Whitney; Hulse, Kathryn E.

Physiology and Immune System Dysfunction. Vol. 5 Elsevier Inc, 2016. p. 306-312.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AU - Hulse, Kathryn E

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N2 - Allergic rhinitis and chronic rhinosinusitis with nasal polyps (CRSwNP) represent two common diseases associated with significant morbidity and socioeconomic burden. Both of these diseases are characterized by type 2 inflammatory responses, but the mechanisms that drive each of these diseases appear to be distinct. While allergic rhinitis is driven by multiple cycles of classic early- and late-phase allergic responses, CRSwNP is driven by unknown chronic inflammatory mechanisms. Further studies are needed to elucidate the mechanisms that result in the formation of chronic type 2 inflammatory responses versus classic allergic reactions. Importantly, new tools and/or animal models are needed to aid mechanistic studies in CRSwNP, which would help to address many of these questions and ultimately improve patient care and quality of life. This article will focus on the epidemiology and the current understanding of the immunologic mechanisms associated with each of these diseases.

AB - Allergic rhinitis and chronic rhinosinusitis with nasal polyps (CRSwNP) represent two common diseases associated with significant morbidity and socioeconomic burden. Both of these diseases are characterized by type 2 inflammatory responses, but the mechanisms that drive each of these diseases appear to be distinct. While allergic rhinitis is driven by multiple cycles of classic early- and late-phase allergic responses, CRSwNP is driven by unknown chronic inflammatory mechanisms. Further studies are needed to elucidate the mechanisms that result in the formation of chronic type 2 inflammatory responses versus classic allergic reactions. Importantly, new tools and/or animal models are needed to aid mechanistic studies in CRSwNP, which would help to address many of these questions and ultimately improve patient care and quality of life. This article will focus on the epidemiology and the current understanding of the immunologic mechanisms associated with each of these diseases.

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KW - Chemokines

KW - Chronic rhinosinusitis

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KW - Dendritic cells

KW - Epithelial cells

KW - IgE

KW - Mast cells

KW - Nasal polyps

KW - Sensitization

KW - T-helper cells

KW - Type 2 inflammation

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Stevens W, Hulse KE. Immunology of Nasal Polyposis and Allergic Rhinitis. In Physiology and Immune System Dysfunction. Vol. 5. Elsevier Inc. 2016. p. 306-312 https://doi.org/10.1016/B978-0-12-374279-7.16006-0