Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

Wooram Park, Andrew C. Gordon, Soojeong Cho, Xiaoke Huang, Kathleen R. Harris, Andrew C. Larson*, Dong Hyun Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.

Original languageEnglish (US)
Pages (from-to)13819-13824
Number of pages6
JournalACS Applied Materials and Interfaces
Volume9
Issue number16
DOIs
StatePublished - Apr 26 2017

Keywords

  • and image-guided therapy
  • cancer immunotherapy
  • interferon-gamma (IFN-γ)
  • microspheres
  • natural killer (NK) cells infiltration

ASJC Scopus subject areas

  • Materials Science(all)

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