Immunopathological mechanisms in multiple sclerosis

Joseph R. Podojil, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Genetic indicators that correlate with a predisposition for multiple sclerosis (MS) have been identified. The expression of specific major histocompatibility complex class II (MHC II) haplotypes and altered variants of costimulatory molecules, for example, cytotoxic T-lymphocyte associated antigen-4 (CTLA-4), are hypothesized to allow for aberrant activation of myelin-specific autoreactive T cells. The current review focuses on possible mechanisms by which the expression of these proteins contribute to disease.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalDrug Discovery Today: Disease Mechanisms
Issue number2
StatePublished - 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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