Immunopathology alters Th17 cell glucocorticoid sensitivity

J. Banuelos; Y. Cao; S. C. Shin; N. Z. Lu

doi:10.1111/all.13051

Immunopathology alters Th17 cell glucocorticoid sensitivity

J. Banuelos, Y. Cao, S. C. Shin, N. Z. Lu^*

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.

Original language	English (US)
Pages (from-to)	331-341
Number of pages	11
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	72
Issue number	3
DOIs	https://doi.org/10.1111/all.13051
State	Published - Mar 1 2017

Funding

This study was funded by the National Institute of Allergy and Infectious Diseases, (R21AI113935), National Heart, Lung, and Blood Institute (R37HL068546), and the Ernest S. Bazley Foundation.

Keywords

Th17 cells
asthma
autoimmunity
glucocorticoid resistance
glucocorticoids

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/all.13051

Cite this

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abstract = "Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.",

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AU - Banuelos, J.

AU - Cao, Y.

AU - Shin, S. C.

AU - Lu, N. Z.

N1 - Funding Information: This study was funded by the National Institute of Allergy and Infectious Diseases, (R21AI113935), National Heart, Lung, and Blood Institute (R37HL068546), and the Ernest S. Bazley Foundation. Publisher Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2017/3/1

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N2 - Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.

AB - Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.

KW - Th17 cells

KW - asthma

KW - autoimmunity

KW - glucocorticoid resistance

KW - glucocorticoids

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JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

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ER -

Immunopathology alters Th17 cell glucocorticoid sensitivity

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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