Abstract
Cancers of the central nervous system (CNS) are unique both in the immunopathology underlying their development and in the challenges they present to designing effective immune-based therapeutic strategies. The immune response in the CNS has fundamental differences from that seen elsewhere in the organism. Moreover, a series of evasion mechanisms have been described for CNS tumors, which limit effective recognition and effective antitumoral cytotoxic responses by the immune system. A series of therapeutic approaches are currently being developed for enhancing and focusing the immune system to elicit and enhance a therapeutic antitumoral response. In this chapter, an overview of the intricacies of the immune system in the CNS within the context of tumor immunology is presented. In addition, some of the most salient immunotherapeutic advances for treatment of CNS tumors are explored.
Original language | English (US) |
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Title of host publication | Cancer Immunology |
Subtitle of host publication | Cancer Immunotherapy for Organ-Specific Tumors |
Publisher | Springer Berlin Heidelberg |
Pages | 333-362 |
Number of pages | 30 |
ISBN (Electronic) | 9783662464106 |
ISBN (Print) | 9783662464090 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- Central nervous system
- Immunology
- Immunotherapy
- Tumor
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology