Immunophenotypic alterations in acute and early HIV infection

Lena Al-Harthi*, Sam MaWhinney, Elizabeth Connick, Robert T. Schooley, Jeri E. Forster, Constance Benson, Melanie Thompson, Franklyn Judson, Frank Joseph Palella Jr, Alan Landay

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To understand the extent of immune dysregulation in primary HIV infection (PHI) and the impact of antiretroviral therapy (ART) on restoring these abnormalities, we longitudinally evaluated 52 subjects (Acute-Treated (AT); Early-Treated (ET); Early Untreated (EU)) for markers of activation, proliferation, and function on T cells. ET and AT patients differed by 0.54 log viral load (VL) at baseline but did not differ thereafter by more than 0.34 log10 VL. AT subjects had higher CD8+ T cell counts and expression of markers indicative of CD8+ T cell activation (CD38), and proliferation (Ki67), at baseline, than ET subjects but were not different 48 weeks post-ART. Although acute PHI is marked by higher level of immune activation than early PHI, virologic and immunologic responses were similar post-ART, suggesting that the extent of immunologic recovery is not negatively impacted by a delay of treatment beyond the acute stage of disease.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalClinical Immunology
Volume125
Issue number3
DOIs
StatePublished - Dec 1 2007

Keywords

  • Acute HIV
  • Early HIV
  • Immune reconstitution
  • Immunophenotyping
  • Primary HIV infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Al-Harthi, L., MaWhinney, S., Connick, E., Schooley, R. T., Forster, J. E., Benson, C., Thompson, M., Judson, F., Palella Jr, F. J., & Landay, A. (2007). Immunophenotypic alterations in acute and early HIV infection. Clinical Immunology, 125(3), 299-308. https://doi.org/10.1016/j.clim.2007.08.011