Immunophenotypic variations in mantle cell lymphoma

Juehua Gao, Lo Ann Peterson, Beverly Nelson, Charles Goolsby, Yi Hua Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Mantle cell lymphoma (MCL) expresses pan-Bcell antigens and is usually CD5+/CD10-/CD23-/ FMC7+. In this study, we evaluated 52 patients with confirmed diagnoses of MCL and identified variant immunophenotypes in 21 patients (19/48 classical and 2/4 variant MCLs), including CD5- in 6 (12%) of 52, CD10+ in 4 (8%) of 50, CD23+ in 10 (21%) of 48, and FMC7- in 4 (11%) of 37 cases. Three cases showed variations in 2 antigens, including CD5-/ CD23+, CD10+/FMC7-, and CD23+/FMC7-; they were all classical MCLs. One blastoid variant MCL was CD23+, and one was FMC7-. Evaluation for proliferation index by immunohistochemical analysis for Ki-67 demonstrated no significant difference between MCLs with variant immunophenotypes and MCLs with typical immunophenotypes. The high proliferation index (>60%) was exclusively seen in the blastoid and pleomorphic variants. Our results indicate that immunophenotypic variations are common in MCL, and recognizing the variability is important for accurate subclassification of B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)699-706
Number of pages8
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 2009


  • Flow cytometry
  • Immunophenotype
  • Ki-67
  • Mantle cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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