ImmunoPods: Polymer shells with native antibody cross-links

Ke Zhang; Dan Zheng; Liangliang Hao; Joshua I. Cutler; Evelyn Auyeung; Chad A. Mirkin

doi:10.1002/anie.201106313

ImmunoPods: Polymer shells with native antibody cross-links

Ke Zhang, Dan Zheng, Liangliang Hao, Joshua I. Cutler, Evelyn Auyeung, Chad A. Mirkin^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.

Original language	English (US)
Pages (from-to)	1169-1172
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/anie.201106313
State	Published - Jan 27 2012

Keywords

HER2
antibodies
gold
nanoparticles
polymers

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201106313

Fingerprint Dive into the research topics of 'ImmunoPods: Polymer shells with native antibody cross-links'. Together they form a unique fingerprint.

Cite this

@article{067b647199ea4dbbb506d5715d3c9cfc,

title = "ImmunoPods: Polymer shells with native antibody cross-links",

abstract = "Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.",

keywords = "HER2, antibodies, gold, nanoparticles, polymers",

author = "Ke Zhang and Dan Zheng and Liangliang Hao and Cutler, {Joshua I.} and Evelyn Auyeung and Mirkin, {Chad A.}",

year = "2012",

month = jan,

day = "27",

doi = "10.1002/anie.201106313",

language = "English (US)",

volume = "51",

pages = "1169--1172",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - ImmunoPods

T2 - Polymer shells with native antibody cross-links

AU - Zhang, Ke

AU - Zheng, Dan

AU - Hao, Liangliang

AU - Cutler, Joshua I.

AU - Auyeung, Evelyn

AU - Mirkin, Chad A.

PY - 2012/1/27

Y1 - 2012/1/27

N2 - Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.

AB - Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.

KW - HER2

KW - antibodies

KW - gold

KW - nanoparticles

KW - polymers

UR - http://www.scopus.com/inward/record.url?scp=84856179637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856179637&partnerID=8YFLogxK

U2 - 10.1002/anie.201106313

DO - 10.1002/anie.201106313

M3 - Article

C2 - 22173847

AN - SCOPUS:84856179637

VL - 51

SP - 1169

EP - 1172

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 5

ER -