ImmunoPods: Polymer shells with native antibody cross-links

Ke Zhang, Dan Zheng, Liangliang Hao, Joshua I. Cutler, Evelyn Auyeung, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.

Original languageEnglish (US)
Pages (from-to)1169-1172
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number5
DOIs
StatePublished - Jan 27 2012

Keywords

  • HER2
  • antibodies
  • gold
  • nanoparticles
  • polymers

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'ImmunoPods: Polymer shells with native antibody cross-links'. Together they form a unique fingerprint.

Cite this