ImmunoPods: Polymer shells with native antibody cross-links

Ke Zhang; Dan Zheng; Liangliang Hao; Joshua I. Cutler; Evelyn Auyeung; Chad A. Mirkin

doi:10.1002/anie.201106313

ImmunoPods: Polymer shells with native antibody cross-links

Ke Zhang, Dan Zheng, Liangliang Hao, Joshua I. Cutler, Evelyn Auyeung, Chad A. Mirkin^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.

Original language	English (US)
Pages (from-to)	1169-1172
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/anie.201106313
State	Published - Jan 27 2012

Keywords

HER2
antibodies
gold
nanoparticles
polymers

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201106313

Cite this

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title = "ImmunoPods: Polymer shells with native antibody cross-links",

abstract = "Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.",

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author = "Ke Zhang and Dan Zheng and Liangliang Hao and Cutler, {Joshua I.} and Evelyn Auyeung and Mirkin, {Chad A.}",

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volume = "51",

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T2 - Polymer shells with native antibody cross-links

AU - Zhang, Ke

AU - Zheng, Dan

AU - Hao, Liangliang

AU - Cutler, Joshua I.

AU - Auyeung, Evelyn

AU - Mirkin, Chad A.

PY - 2012/1/27

Y1 - 2012/1/27

N2 - Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.

AB - Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.

KW - HER2

KW - antibodies

KW - gold

KW - nanoparticles

KW - polymers

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 5

ER -

ImmunoPods: Polymer shells with native antibody cross-links

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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