Abstract
Nanopods functionalized with anti-HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross-linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod-protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.
Original language | English (US) |
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Pages (from-to) | 1169-1172 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 5 |
DOIs | |
State | Published - Jan 27 2012 |
Keywords
- HER2
- antibodies
- gold
- nanoparticles
- polymers
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)