Immunoregulation by T cells. I. Characterization of the IE(k)-specific Lbd self-reactive T cell clone that helps, suppresses and contrasuppresses B cell responses

J. Quintans, H. Suzuki, J. A. Sosman, P. D. Shah

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

This paper describes an L3T4+, Lyt-2- cloned T cell line of CBA/N origin that is specific for IE(k)-encoded products. Splenic dendritic cells are the predominant stimulatory populations for Lbd cells, being approximately 100 times more effective than large activated B cells. Small B cells and T cells are nonstimulatory. Ldb cells help large B cells to make polyclonal antibody responses, but are unable to activate small B cells and to replace antigen-specific helper T cells in T cell-dependent responses to phosphorylcholine or sheep red blood cells. In the presence of antigen-specific helper T cells, Ldb can amplify, suppress, or contrasuppress T cell funciton, depending on the type and relative ratios of antigen-reactive cells. We explain our findings as a consequence of the self reactivity among helper T cells.

Original languageEnglish (US)
Pages (from-to)1974-1981
Number of pages8
JournalJournal of Immunology
Volume136
Issue number6
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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