Immunoregulation of contact sensitivity

H. N. Claman, S. D. Miller

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Contact sensitivity to dinitro-fluorobenzene in the mouse is a form of delayed-type hypersensitivity. This reaction is closely regulated. Tolerance to contact sensitivity is mediated by at least 2 mechanisms, tolerance without demonstrable suppressor cells and tolerance with suppressor T cells. Suppressor T cells can inhibit either the afferent limb of sensitization or the efferent (elicitation) phase. These cells probably operate via soluble suppressor factors and require auxiliary cells. The duration of contact sensitivity itself is controlled by another mechanism, which is antibody. This antibody is directed against the T cells responsible for the delayed hypersensitivity state (T[DH]), and down-regulate these cells. It is antigen-specific and has the properties of an antireceptor (anti-idiotypic) antibody.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalJournal of Investigative Dermatology
Volume74
Issue number5
DOIs
StatePublished - Jan 1 1980

Fingerprint

T-cells
Contact Dermatitis
Delayed Hypersensitivity
Fluorobenzenes
T-Lymphocytes
Antibodies
Anti-Idiotypic Antibodies
Antigens
Down-Regulation
Extremities

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

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abstract = "Contact sensitivity to dinitro-fluorobenzene in the mouse is a form of delayed-type hypersensitivity. This reaction is closely regulated. Tolerance to contact sensitivity is mediated by at least 2 mechanisms, tolerance without demonstrable suppressor cells and tolerance with suppressor T cells. Suppressor T cells can inhibit either the afferent limb of sensitization or the efferent (elicitation) phase. These cells probably operate via soluble suppressor factors and require auxiliary cells. The duration of contact sensitivity itself is controlled by another mechanism, which is antibody. This antibody is directed against the T cells responsible for the delayed hypersensitivity state (T[DH]), and down-regulate these cells. It is antigen-specific and has the properties of an antireceptor (anti-idiotypic) antibody.",
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Immunoregulation of contact sensitivity. / Claman, H. N.; Miller, S. D.

In: Journal of Investigative Dermatology, Vol. 74, No. 5, 01.01.1980, p. 263-266.

Research output: Contribution to journalArticle

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