Abstract
We have described a cloned dendritic cell, Clone Den-1, which is a potent accessory cell for some T-dependent immune responses. Clone Den-1 activates T cells in both autologous and allogeneic mixed lymphocyte reactions, but cannot present soluble antigen to T cells that co-recognize nominal antigen plus I-Ab gene products. In addition, Clone Den-1 or factors produced by it can reconstitute plaque-forming cell responses by accessory cell-depleted B plus T cells to the T-dependent antigen sheep red blood cells. The relationship of this clone to heterogeneous populations of dendritic cells and other accessory cells is discussed.
Original language | English (US) |
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Pages (from-to) | 1174-1178 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 133 |
Issue number | 3 |
State | Published - 1984 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology