Immunoregulation of T-dependent responses by a cloned dendritic cell

C. Clayberger, R. H. DeKruyff, R. Fay, M. Pavlakis, H. Cantor

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We have described a cloned dendritic cell, Clone Den-1, which is a potent accessory cell for some T-dependent immune responses. Clone Den-1 activates T cells in both autologous and allogeneic mixed lymphocyte reactions, but cannot present soluble antigen to T cells that co-recognize nominal antigen plus I-Ab gene products. In addition, Clone Den-1 or factors produced by it can reconstitute plaque-forming cell responses by accessory cell-depleted B plus T cells to the T-dependent antigen sheep red blood cells. The relationship of this clone to heterogeneous populations of dendritic cells and other accessory cells is discussed.

Original languageEnglish (US)
Pages (from-to)1174-1178
Number of pages5
JournalJournal of Immunology
Volume133
Issue number3
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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