Immunoregulatory activities of autoreactive T cells: An I-A-specific T cell clone mediates both help and suppression of antibody responses

C. Clayberger, R. H. Dekruyff, H. Cantor

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

We have derived a Ly-1+, 2-3- T cell clone that is specific for autologous I-A on activated but not on resting cells. After activation, this clone produces factors that induce purified (B + adherent) cells to secrete antibody in response to sheep red blood cells and type 2 T-independent antigens. Regulation of plaque-forming cell responses by this clone is dose dependent: low numbers enhance the plaque-forming cell response, whereas high numbers suppress the response. The inhibition observed with high doses is associated with cytolysis of I-A+ cells, and this can be blocked by the addition of anti-I-A antibodies. The physiologic significance of this novel cell type in regulating immune responses is discussed.

Original languageEnglish (US)
Pages (from-to)2237-2243
Number of pages7
JournalJournal of Immunology
Volume132
Issue number5
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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