Immunoregulatory effects of total glucosides of paeony (TGP), paeoniflorin (PF) and TGP removed PF on adjuvant arthritic rats

Zhi-Dong Ge*, A. W. Zhou, B. Wang

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

On day 18 post Freunds complete adjuvant injection, concanavalin A (Con A)-induced splenic lymphocyte proliferation in rats was suppressed markedly, and peritoneal macrophages (PMΦs) from arthritic rats induced by lipopolysaccharide (LPS) produced interleukin 1 (IL-1) much more than that of the control group. TGP, PF and TGP removed PF (TGP-PF) (0.5 ~ 312.5 mg · L-1) possessed the promoting effect on the splenic lymphocyte proliferation and the inhibitory effect on the IL-1 production. Their concentration-effect curves were bell-shaped in Con A-induced splenic lymphocyte proliferation and upside-down bell-shaped in LPS-induced IL-1 production. The immunoregulatory actions of TGP (2.5 ~ 62.5 mg · L-1) on adjuvant arthritic rats were more potent than that of the same concentration of either TGP or TGP-PF. The results suggested that all TGP, PF and TGP-PF possess a dual immunomodulatory effect on the splenic lymphocyte proliferation and IL-1 production by PMΦs from adjuvant arthritic rats, depending upon their concentration and the functional state of animals, in which TGP is the most potent.

Original languageEnglish (US)
Pages (from-to)303-305
Number of pages3
JournalChinese Pharmacological Bulletin
Volume11
Issue number4
StatePublished - Jan 1 1995

Keywords

  • immunoregulation
  • interleukin 1
  • lymphocyte transformation
  • paeoniflorin
  • total glucosides of paeony
  • total glucosides of paeony removed paeoniflorin

ASJC Scopus subject areas

  • Pharmacology

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