Immunosenescence: the Role of Aging in the Predisposition to Neuro-Infectious Complications Arising from the Treatment of Multiple Sclerosis

Elena Grebenciucova*, Joseph R. Berger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Purpose of Review: This review highlights some of the important changes in the immune system that occur in the process of normal aging. Immunosenescence as a concept is directly relevant to the world of neuro-inflammation, as it may be a contributing factor to the risks associated with some of the current immunosuppressive and immunomodulatory therapies used in treating multiple sclerosis (MS) and other inflammatory disorders. Recent Findings: Profound qualitative and quantitative changes occur in the adaptive and innate immunity compartments during aging. These changes may explain why patients of older age are at an increased risk of infections and infection-associated mortality. Summary: Immunosenescence-associated changes may be additive or synergistic with the effects produced by immunomodulatory and immunosuppressive medications. Clinicians should exercise a high level of vigilance in monitoring the risk of infections in older patients on these treatments.

Original languageEnglish (US)
Article number61
JournalCurrent Neurology and Neuroscience Reports
Volume17
Issue number8
StatePublished - Aug 1 2017

Keywords

  • CNS opportunistic infections
  • Disease modifying therapy
  • Immune system
  • Immunosenescence
  • Multiple sclerosis
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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